[Lynch syndrome: genetics and surgery].
نویسندگان
چکیده
Hereditary nonpolyposis colorectal cancer or Lynch Syndrome, caused by germinal mutations in mismatch deoxyribonucleic acid (DNA) repair genes, is the most common form of hereditary colorectal cancer. The identification of these individuals is not easy and is based on clinical and molecular criteria. A review is presented on the genetics and diagnosis in Lynch Syndrome, as well as on its surgical management and prevention.
منابع مشابه
Hereditary Nonpolyposis Colorectal Cancer (HNPCC)/Lynch Syndrome: Surveillance and Diagnostic strategies
Introduction: Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is an autosomal dominant genetic disease. The disease is caused by a mutation in one of four genes of the DNA mismatch repair system and increases the risk for various cancers, especially the uterine and colon cancers. The prevalence of this disease in the general population is about 1 in 500 and it causes about 2-3...
متن کاملLynch Syndrome: Awareness among Medical Students at a United States Medical School
INTRODUCTION: Lynch syndrome was first described in the 1950s however until recently it was rarely included in medical school curricula. As a result, many practicing physicians have limited exposure, potentially contributing to significant under diagnosis. As identification of Lynch syndrome prior to malignancy allows for intensified screening, prophylactic surgery and improved patient outcomes...
متن کاملسندرم Lynch -l و گزارش شش مورد بیمار مبتلا
More than two decades ago, Henry T. Lynch reported a hereditary non polyposis colorectal cancer (HNPCC) which is seen in some families with dominant mode of inheritance, also know as Lynch Syndrome type I and II. This form to hereditary colorectal cancer has an early age of onset (Less than 45 years) with predominantly proximal colonic involvement (type I) and can also be associated with extrac...
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HNPCC (Lynch syndrome) is the most common form of hereditary colorectal cancer (CRC), wherein it accounts for between 2-7 percent of the total CRC burden. When considering the large number of extracolonic cancers integral to the syndrome, namely carcinoma of the endometrium, ovary, stomach, hepatobiliary system, pancreas, small bowel, brain tumors, and upper uroepithelial tract, these estimates...
متن کاملLetter to the Editor regarding the manuscript entitled: "Prevalence of occult gynecologic malignancy at the time of risk reducing and nonprophylactic surgery in patients with Lynch syndrome" by Lachiewicz et al. (Gynecol Oncol. 2014; 132: 434-437).
I was interested to read the article by Lachiewicz and colleagues that appeared in a recent issue of Gynecologic Oncology (Lachiewicz et al., 2014). The authors conducted a retrospective chart review of patients with Lynch syndrome who had undergone surgery (hysterectomy and/or bilateral salpingo-oophorectomy); their purpose was to determine the prevalence of occult malignancy found during oper...
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ورودعنوان ژورنال:
- Cirugia espanola
دوره 89 1 شماره
صفحات -
تاریخ انتشار 2011